Zarrindast Mohammad-Reza, Bananej Maryam, Khalilzadeh Azita, Fazli-Tabaei Soheila, Haeri-Rohani Ali, Rezayof Ameneh
Department of Pharmacology, School of Medicine and Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran.
Neurobiol Learn Mem. 2006 Nov;86(3):286-92. doi: 10.1016/j.nlm.2006.04.002. Epub 2006 May 24.
The effects of dopaminergic drugs on morphine state-dependent memory of passive avoidance task were examined in mice. Pre-training administration of morphine (5mg/kg) led to state-dependent learning with impaired memory retrieval on the test day which was reversed by pre-test administration of the same dose of the opiate. The pre-test intracerebroventricular (i.c.v.) administration of the dopamine D1 receptor agonist (SKF38393), dopamine D2 receptor agonist (quinpirole) and dopamine D2 receptor antagonist (sulpiride) not only reversed the effect of pre-training morphine treatment, but also increased this action of the drug. Furthermore, the pre-test i.c.v. administration of dopamine D1 receptor antagonist (SCH23390) prevented the restoration of memory by morphine. In conclusion, the morphine-induced recovery of memory, on the test day, seems to be induced, at least in part, through dopamine receptors.
研究了多巴胺能药物对小鼠吗啡状态依赖性被动回避任务记忆的影响。吗啡（5mg/kg）预训练给药导致状态依赖性学习，在测试日记忆恢复受损，而相同剂量的阿片类药物预测试给药可逆转这种情况。多巴胺D1受体激动剂（SKF38393）、多巴胺D2受体激动剂（喹吡罗）和多巴胺D2受体拮抗剂（舒必利）的预测试脑室内（i.c.v.）给药不仅逆转了预训练吗啡治疗的效果，还增强了药物的这种作用。此外，多巴胺D1受体拮抗剂（SCH23390）的预测试i.c.v.给药可阻止吗啡恢复记忆。总之，吗啡在测试日诱导的记忆恢复似乎至少部分是通过多巴胺受体介导的。
