Wulf Gerburg, Finn Greg, Suizu Futoshi, Lu Kun Ping
Cancer Biology Program, Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Avenue Louis Pasteur, NRB 1030, Boston, MA 02115, USA.
Nat Cell Biol. 2005 May;7(5):435-41. doi: 10.1038/ncb0505-435.
The prolyl isomerase Pin1 is a conserved enzyme that is intimately involved in diverse biological processes and pathological conditions such as cancer and Alzheimer's disease. By catalysing cis-trans interconversion of certain motifs containing phosphorylated serine or threonine residues followed by a proline residue (pSer/Thr-Pro), Pin1 can have profound effects on phosphorylation signalling. The structural and functional differences that result from cis-trans isomerization of specific pSer/Thr-Pro motifs probably underlie most, if not all, Pin1-dependent actions. Phosphorylation-dependent prolyl isomerization by Pin1 remains a unique mode for the modulation of signal transduction. Here, we provide an overview of the plethora of regulatory events that involve this unique enzyme, with a particular focus on oncogenic signalling and neurodegeneration.
脯氨酰异构酶Pin1是一种保守酶，密切参与多种生物过程以及癌症和阿尔茨海默病等病理状况。通过催化某些含有磷酸化丝氨酸或苏氨酸残基且其后紧跟一个脯氨酸残基（pSer/Thr-Pro）的基序的顺反异构化，Pin1可对磷酸化信号传导产生深远影响。特定pSer/Thr-Pro基序的顺反异构化所导致的结构和功能差异可能是Pin1依赖性作用的大部分（即便不是全部）作用的基础。Pin1介导的磷酸化依赖性脯氨酰异构化仍然是调节信号转导的一种独特模式。在此，我们概述了涉及这种独特酶的大量调控事件，尤其关注致癌信号传导和神经退行性变。
