Kidgell Claire, Winzeler Elizabeth A
Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, ICND202, La Jolla, CA 92037, USA.
Chromosome Res. 2005;13(3):225-35. doi: 10.1007/s10577-005-1503-6.
DNA microarrays, initially designed to measure gene expression levels, also provide an ideal platform for determining genetic diversity. Oligonucleotide microarrays, predominantly high-density oligonucleotide arrays, have emerged as the principal platforms for performing genome-wide diversity analysis. They have wide-ranging potential applications including comparative genomics, polymorphism discovery and genotyping. The identification of inheritable genetic markers also permits the analysis of quantitative traits, population studies and linkage analysis. In this review, we will discuss the application of oligonucleotide arrays, in particular high-density oligonucleotide arrays for elucidating genetic diversity and highlight some of the directions that the field may take.
DNA微阵列最初设计用于测量基因表达水平，同时也为确定遗传多样性提供了理想的平台。寡核苷酸微阵列，主要是高密度寡核苷酸阵列，已成为进行全基因组多样性分析的主要平台。它们具有广泛的潜在应用，包括比较基因组学、多态性发现和基因分型。可遗传遗传标记的识别还允许对数量性状、群体研究和连锁分析进行分析。在本综述中，我们将讨论寡核苷酸阵列，特别是高密度寡核苷酸阵列在阐明遗传多样性方面的应用，并突出该领域可能发展的一些方向。
