Zhang Xinan, Simon Richard
Biometric Research Branch, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892-7434, USA.
Breast Cancer Res Treat. 2005 May;91(2):121-4. doi: 10.1007/s10549-004-5782-y.
We used multistage models that incorporate the age dependent dynamics of normal breast tissue, clonal expansion of intermediate cells and mutational events to fit data for the age-specific incidence of breast cancers in the surveillance, epidemiology, and end results (SEER) registry. Our results suggest that two or three rate limiting events occurring at rates characteristic of point mutation rates for normal mammalian cells set in motion a sequence of other genomic changes that lead with high probability to breast carcinoma.
我们使用了多阶段模型，该模型纳入了正常乳腺组织随年龄变化的动态、中间细胞的克隆扩增以及突变事件，以拟合监测、流行病学和最终结果（SEER）登记处中乳腺癌年龄特异性发病率的数据。我们的结果表明，以正常哺乳动物细胞点突变率特征的速率发生的两到三个限速事件启动了一系列其他基因组变化，这些变化极有可能导致乳腺癌。
