Cardona Fernando, Tinahones Francisco J, Collantes Eduardo, Garcia-Fuentes Eduardo, Escudero Alejandro, Soriguer Federico
Endocrinology and Nutrition Service, Hospital Civil, Carlos Haya University Hospital, Málaga, Spain.
J Rheumatol. 2005 May;32(5):903-5.
The apolipoprotein AI-CIII-AIV cluster has been associated with the response to a urate-lowering diet, and polymorphisms in the apolipoprotein CIII gene have been associated with hyperuricemia and hypertriglyceridemia. We assessed the influence of polymorphisms in the apolipoprotein AI-CIII-AIV cluster on the response to a urate-lowering diet in patients with hyperuricemia.
A urate-lowering diet was followed for 2 weeks by 64 men with hyperuricemia. Plasma concentrations of triglycerides, cholesterol, glucose, and uric acid, and the uric acid clearance and 24-hour uric acid urinary excretory fraction were measured before and after the diet. The data were analyzed in association with the polymorphisms of the apolipoprotein AI-CIII-AIV gene cluster.
After the urate-lowering diet, the plasma levels of triglycerides, cholesterol, glucose, and uric acid and 24-hour uric acid excretion all fell significantly. Paired sample ANOVA showed that the decrease was mainly due to the diet, except for the plasma triglycerides, which were influenced by allele X2 of the XmnI polymorphism of the apolipoprotein AI gene.
The response of the biological variables to a urate-lowering diet was mainly influenced by diet. Changes in triglycerides were also influenced by the apolipoprotein AI XmnI polymorphism (p = 0.04), suggesting a gene-diet interaction (p = 0.03).
载脂蛋白AI - CIII - AIV基因簇与降尿酸饮食的反应相关，且载脂蛋白CIII基因多态性与高尿酸血症和高甘油三酯血症有关。我们评估了载脂蛋白AI - CIII - AIV基因簇多态性对高尿酸血症患者降尿酸饮食反应的影响。
64名高尿酸血症男性遵循降尿酸饮食2周。在饮食前后测量血浆甘油三酯、胆固醇、葡萄糖和尿酸浓度，以及尿酸清除率和24小时尿酸尿排泄分数。结合载脂蛋白AI - CIII - AIV基因簇的多态性对数据进行分析。
降尿酸饮食后，血浆甘油三酯、胆固醇、葡萄糖和尿酸水平以及24小时尿酸排泄均显著下降。配对样本方差分析表明，除血浆甘油三酯受载脂蛋白AI基因XmnI多态性的X2等位基因影响外，下降主要归因于饮食。
生物变量对降尿酸饮食的反应主要受饮食影响。甘油三酯的变化也受载脂蛋白AI XmnI多态性影响（p = 0.04），提示存在基因 - 饮食相互作用（p = 0.03）。
