Makani J
Department of Internal Medicine, Muhimbili University College of Health Sciences, P. O. Box 65001, Dar es Salaam, Tanzania.
East Afr Med J. 2004 Dec;81(12):657-9. doi: 10.4314/eamj.v81i12.9253.
Stroke, including asymptomatic cerebrovascular events, is a significant cause of morbidity and mortality in sickle cell disease, occurring with an incidence of 10 to 25%. Extensive research has established that cerebral stenosis, involving the circle of Willis, is the most common mechanism in children. We report a child with sickle cell disease who presented with cortical blindness and right-sided hemiplegia. Computerised tomography of the brain revealed an infarct involving the left parietal region and extending to the occipital region. Stroke in SCD is multifactorial, but high-risk individuals can be identified by simple well-established strategies such as transcranial doppler ultrasonography. There are approaches for both primary and secondary interventions, which have been shown to be effective and need to be incorporated into management guidelines for SCD patients. Before schemes are recommended into health care policies, research in the appropriate setting is required.
中风，包括无症状脑血管事件，是镰状细胞病发病和死亡的重要原因，发病率为10%至25%。广泛的研究已证实，累及 Willis 环的脑动脉狭窄是儿童中最常见的机制。我们报告了一名患有镰状细胞病的儿童，该儿童出现皮质盲和右侧偏瘫。脑部计算机断层扫描显示梗死灶累及左顶叶区域并延伸至枕叶区域。镰状细胞病中的中风是多因素的，但高危个体可通过经颅多普勒超声等简单且成熟的策略来识别。对于一级和二级干预都有相应方法，这些方法已被证明是有效的，需要纳入镰状细胞病患者的管理指南中。在将方案推荐纳入医疗保健政策之前，需要在适当的环境中进行研究。
