Schatz J, Brown R T, Pascual J M, Hsu L, DeBaun M R
Department of Psychology, University of South Carolina, Columbia 29208, USA.
Neurology. 2001 Apr 24;56(8):1109-11. doi: 10.1212/wnl.56.8.1109.
The authors evaluated education attainment and neuropsychological deficits in children with sickle cell disease (SCD) and silent cerebral infarcts. Children with silent infarcts had twice the rate of school difficulties as children without infarcts. Eighty percent of silent infarct cases had clinically significant cognitive deficits, whereas 35% had deficits in academic skills. Children with silent cerebral infarcts show high rates of poor educational attainment, cognitive deficits, and frontal lobe injury. Poor school performance in SCD is one indicator of silent infarcts.
作者评估了镰状细胞病（SCD）合并无症状脑梗死患儿的教育程度和神经心理缺陷。有无症状脑梗死的患儿出现学习困难的几率是无梗死患儿的两倍。80%的无症状梗死患儿有具有临床意义的认知缺陷，而35%的患儿存在学术技能缺陷。有无症状脑梗死的患儿表现出教育程度低、认知缺陷和额叶损伤的比例很高。SCD患儿学习成绩差是无症状梗死的一个指标。
