通过立体选择性水解对磷脂双层膜进行酶促光刻。
Enzymatic lithography of phospholipid bilayer films by stereoselective hydrolysis.
作者信息
Moraille Patricia, Badia Antonella
机构信息
Department of Chemistry and Centre for Self-Assembled Chemical Structures, Université de Montréal, C.P. 6128, succursale Centre-ville, Montréal, Quebec H3C 3J7, Canada.
出版信息
J Am Chem Soc. 2005 May 11;127(18):6546-7. doi: 10.1021/ja0511669.
The stereoselective phospholipase A2-catalyzed hydrolysis of patterned phospholipid bilayers consisting of the l- and d-isomers of alpha-dilauroylphosphatidylcholine (DLPC) and alpha-dipalmitoylphosphatidylcholine (DPPC) is reported. The stereochemically directed enzyme lithography demonstrated herein allows the parallel modification of large surface areas and constitutes a potentially useful method to structure biomimetic films, given the stereospecific action of many enzymes.
报道了立体选择性磷脂酶A2催化水解由α-二月桂酰磷脂酰胆碱（DLPC）和α-二棕榈酰磷脂酰胆碱（DPPC）的L-和D-异构体组成的图案化磷脂双层。本文展示的立体化学定向酶光刻技术能够对大面积进行平行修饰，鉴于许多酶的立体特异性作用，这构成了一种构建仿生膜的潜在有用方法。
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