牛间充质干细胞对牛疱疹病毒4的易感性。

Susceptibility of bovine mesenchymal stem cells to bovine herpesvirus 4.

作者信息

Donofrio G, Colleoni S, Galli C, Lazzari G, Cavirani S, Flammini C F

机构信息

Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali, Facoltà di Medicina Veterinaria, Via del Taglio 8, 43100 Parma, Italy.

出版信息

J Virol Methods. 2005 Aug;127(2):168-70. doi: 10.1016/j.jviromet.2005.02.019.

DOI:10.1016/j.jviromet.2005.02.019

PMID:15869810

Abstract

Bovine herpesvirus 4 (BoHV-4) is a gamma herpesvirus with no clear disease association. Previous studies have demonstrated that macrophages can harbour persistent BoHV-4. Since mesenchymal stem cells in bone marrow regulate the differentiation and proliferation of adjacent haematopoietic precursors, such as macrophages, the interaction between BoHV-4 and mesenchymal stem cells was investigated. Primary bovine mesenchymal stem cells were highly permissive to support full replication of BoHV-4. This finding could be considered a new important step in studies on the potential pathogenesis related to BoHV-4.

摘要

牛疱疹病毒4型（BoHV-4）是一种γ疱疹病毒，与明确的疾病关联不明显。先前的研究表明，巨噬细胞可携带持续性BoHV-4。由于骨髓间充质干细胞调节相邻造血前体细胞（如巨噬细胞）的分化和增殖，因此对BoHV-4与间充质干细胞之间的相互作用进行了研究。原代牛间充质干细胞对支持BoHV-4的完全复制高度敏感。这一发现可被视为BoHV-4相关潜在发病机制研究中的一个新的重要进展。