Merlo Barbara, Gugole Penelope Maria, Iacono Eleonora
Department of Veterinary Medical Sciences, University of Bologna, 40064 Ozzano Emilia, BO, Italy.
Interdepartmental Center for Industrial Research in Health Sciences and Technologies, University of Bologna, 40126 Bologna, BO, Italy.
Animals (Basel). 2022 Aug 2;12(15):1956. doi: 10.3390/ani12151956.
Attention on mesenchymal stromal cells (MSCs) research has increased in the last decade mainly due to the promising results about their plasticity, self-renewal, differentiation potential, immune modulatory and anti-inflammatory properties that have made stem cell therapy more clinically attractive. Furthermore, MSCs can be easily isolated and expanded to be used for autologous or allogenic therapy following the administration of either freshly isolated or previously cryopreserved cells. The scientific literature on the use of stromal cells in the treatment of several animal health conditions is currently available. Although MSCs are not as widely used for clinical treatments in cows as for companion and sport animals, they have the potential to be employed to improve productivity in the cattle industry. This review provides an update on state-of-the-art applications of bovine MSCs to clinical treatments and reproductive biotechnologies.
在过去十年中，对间充质基质细胞（MSCs）的研究关注度有所增加，这主要是因为其可塑性、自我更新能力、分化潜能、免疫调节和抗炎特性带来了令人鼓舞的结果，这些特性使得干细胞疗法在临床上更具吸引力。此外，间充质基质细胞易于分离和扩增，可在注射新鲜分离或先前冷冻保存的细胞后用于自体或异体治疗。目前已有关于使用基质细胞治疗多种动物健康状况的科学文献。尽管间充质基质细胞在奶牛临床治疗中的应用不如在伴侣动物和运动动物中广泛，但它们有潜力用于提高养牛业的生产力。本综述提供了关于牛间充质基质细胞在临床治疗和生殖生物技术方面的最新应用情况。
