Greene Landon R, Blackburn Anthony C, Miller Jonathan M
Pharmaceutical Research and Development, World Wide Pharmaceutical Sciences, Pfizer Global Research and Development-Ann Arbor Laboratories, MI 48105, USA.
J Pharm Biomed Anal. 2005 Sep 1;39(1-2):344-7. doi: 10.1016/j.jpba.2005.03.022.
A rapid gravimetric method for determining drug candidate solubility in organic solvents has been developed. The scale, speed, precision, and accuracy of the method make it ideal for solubility screening of pharmaceutical compounds during early development. The method utilizes a thermogravimetric analyzer to automate drying and weighing. Results for model compounds compare favorably with literature values.
已开发出一种快速重量法来测定候选药物在有机溶剂中的溶解度。该方法的规模、速度、精密度和准确度使其成为药物化合物早期开发阶段溶解度筛选的理想方法。该方法利用热重分析仪实现干燥和称重自动化。模型化合物的结果与文献值相比具有优势。
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