Shimbo Kazutaka, Nozawa Kohei, Tsuda Masashi, Kobayashi Jun'ichi
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Bioorg Med Chem. 2005 Sep 1;13(17):5066-71. doi: 10.1016/j.bmc.2005.04.021.
Solution conformations of amphidinolide H (1), a 26-membered macrolide exhibiting potent cytotoxic and antitumor activity, in CDCl3 and DMSO-d6 were investigated on the basis of NMR data, distance geometry calculation, and restrained energy minimization. Three-dimensional conformations in CDCl3 were suggested to be close to the X-ray structure of 1, while those in DMSO-d6 were indicated to be different from both those in CDCl3 and the X-ray structure.
