两性霉素Q的绝对立体化学

Absolute stereochemistry of amphidinolide Q.

作者信息

Takahashi Yohei, Kubota Takaaki, Fukushi Eri, Kawabata Jun, Kobayashi Jun'ichi

机构信息

Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

出版信息

Org Lett. 2008 Sep 4;10(17):3709-11. doi: 10.1021/ol8013123. Epub 2008 Aug 5.

DOI:10.1021/ol8013123

PMID:18680307

Abstract

The absolute configurations at five chiral centers in amphidinolide Q (1), a cytotoxic 12-membered macrolide isolated from a marine dinoflagellate Amphidinium sp., were elucidated to be 4R, 7R, 9S, 11R, and 13R on the basis of NMR analyses and a modified Mosher's method.

摘要

从海洋双鞭毛藻Amphidinium sp.中分离得到的具有细胞毒性的12元大环内酯两性霉素Q（1）中五个手性中心的绝对构型，通过核磁共振分析和改良的莫舍尔方法确定为4R、7R、9S、11R和13R。