Nagata Toshiaki, Uemoto Masaharu, Yuzuriha Hideki, Asakawa Akihiro, Inui Akio, Fujimiya Mineko, Sakamaki Ruka, Kasuga Masato, Shinfuku Naotaka
Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Int J Mol Med. 2005 Jun;15(6):1041-3.
Urocortin, a recently identified member of the corticotropin-releasing factor (CRF) family, is implicated in the central control of appetite and energy metabolism. We previously reported that peripherally administered urocortin inhibits gastric emptying in conscious mice. In this study, we investigated the effect of intracerebroventricularly administered urocortin on gastric emptying, food intake and body weight in mice. Urocortin decreased food intake and body weight gain more potently than CRF. It significantly decreased gastric emptying of a solid meal; an effect that was inhibited by simultaneous administration of alpha-helical CRF9-41, a CRF antagonist. These results suggest that the potent anorectic properties of urocortin may be partly due to the anti-gastroprokinetic activity of the peptide.
尿皮质素是促肾上腺皮质激素释放因子（CRF）家族中最近发现的成员，与食欲和能量代谢的中枢控制有关。我们之前报道过，外周给予尿皮质素可抑制清醒小鼠的胃排空。在本研究中，我们研究了脑室内给予尿皮质素对小鼠胃排空、食物摄入和体重的影响。尿皮质素比CRF更有效地降低食物摄入量和体重增加。它显著降低了固体食物的胃排空；同时给予CRF拮抗剂α-螺旋CRF9-41可抑制这一作用。这些结果表明，尿皮质素强大的厌食特性可能部分归因于该肽的抗胃促动力活性。
