促肾上腺皮质激素释放因子家族肽的厌食活性比较。
Comparison of the anorexigenic activity of CRF family peptides.
作者信息
Tanaka Chie, Asakawa Akihiro, Ushikai Miharu, Sakoguchi Takeo, Amitani Haruka, Terashi Mutsumi, Cheng KaiChun, Chaolu Huhe, Nakamura Norifumi, Inui Akio
机构信息
Division of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan.
出版信息
Biochem Biophys Res Commun. 2009 Dec 18;390(3):887-91. doi: 10.1016/j.bbrc.2009.10.069. Epub 2009 Oct 20.
Corticotropin releasing factor (CRF) family peptides have an important role in the control of food intake. We investigated the effects of CRF family peptides on food intake and body weight gain in mice. Of the CRF family peptides, including CRF, urocortin1 (Ucn1), urocortin2 (Ucn2) and urocortin3 (Ucn3), peripherally administered Ucn1 was shown to have the most potent inhibitory effect on the food intake and body weight gain of both lean and high fat fed obese mice. In addition, repeated administration of Ucn1 lowered blood glucose and acylated ghrelin, and decreased the visceral fat weight of high fat fed obese mice.
促肾上腺皮质激素释放因子（CRF）家族肽在食物摄入控制中起重要作用。我们研究了CRF家族肽对小鼠食物摄入和体重增加的影响。在包括CRF、尿皮质素1（Ucn1）、尿皮质素2（Ucn2）和尿皮质素3（Ucn3）在内的CRF家族肽中，外周给予Ucn1对瘦小鼠和高脂喂养的肥胖小鼠的食物摄入和体重增加具有最显著的抑制作用。此外，重复给予Ucn1可降低血糖和酰化胃饥饿素，并减少高脂喂养肥胖小鼠的内脏脂肪重量。
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