印度钦奈儿童血铅水平与神经行为功能的一项试点研究。
A pilot study of blood lead levels and neurobehavioral function in children living in Chennai, India.
作者信息
Bellinger David C, Hu Howard, Kalaniti Kartigeyan, Thomas Naveen, Rajan Pradeep, Sambandam Sankar, Ramaswamy Padmavathi, Balakrishnan Kalpana
机构信息
Department of Neurology, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Int J Occup Environ Health. 2005 Apr-Jun;11(2):138-43. doi: 10.1179/oeh.2005.11.2.138.
The relationship between blood lead level and neurodevelopment was assessed in a pilot cross-sectional study of 74 4-14-year-old children in Chennai, India. Mean blood lead level was 11.1 microg/dL (2.5-38.3). The Binet-Kamath IQ test and the Wide Range Assessment of Visual Motor Activity (WRAVMA) were administered to 58 children. Teachers completed the Connor's Behavioral Rating Scale. Excluding two outliers, IQ and WRAVMA composite scores were inversely related to blood lead level, with an effect size of approximately 6 points decline for a 10-microg/dL increase in blood lead. Children in the highest and lowest blood lead quartiles had mean IQs of 95.6+/-13.3 and 102.0+/-22.5, respectively. Behavior ratings were not associated with blood lead level. Lead exposure is a significant problem among Indian children, with many having blood lead levels associated with increased neurodevelopmental risk.
在印度金奈对74名4至14岁儿童进行的一项初步横断面研究中，评估了血铅水平与神经发育之间的关系。平均血铅水平为11.1微克/分升（2.5 - 38.3）。对58名儿童进行了比奈 - 卡马特智商测试和视觉运动活动广泛评估（WRAVMA）。教师完成了康纳行为评定量表。排除两个异常值后，智商和WRAVMA综合得分与血铅水平呈负相关，血铅每增加10微克/分升，效应大小约为智商下降6分。血铅水平处于最高和最低四分位数的儿童，平均智商分别为95.6±13.3和102.0±22.5。行为评定与血铅水平无关。铅暴露在印度儿童中是一个重大问题，许多儿童的血铅水平与神经发育风险增加相关。
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