通过聚焦微波加热使腈三聚化形成4-氨基嘧啶。
Formation of 4-aminopyrimidines via the trimerization of nitriles using focused microwave heating.
作者信息
Baxendale Ian R, Ley Steven V
机构信息
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.
出版信息
J Comb Chem. 2005 May-Jun;7(3):483-9. doi: 10.1021/cc049826d.
PMID:15877477
Abstract
A series of substituted aliphatic nitriles have been trimerized to their corresponding pyrimidine structures under solvent-free conditions in the presence of catalytic quantities of potassium tert-butoxide using a focused microwave reactor. Multigram quantities of the corresponding 4-aminopyrimidines have been prepared in high yields and purity following a simple and scaleable protocol.
摘要
在聚焦微波反应器中，在催化量的叔丁醇钾存在下，一系列取代脂肪腈在无溶剂条件下三聚化为相应的嘧啶结构。按照简单且可扩展的方案，已高收率和高纯度地制备了多克量的相应4-氨基嘧啶。
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