Wilkinson Alan, Davidson Jaime, Dotta Francesco, Home Philip D, Keown Paul, Kiberd Bryce, Jardine Alan, Levitt Naomi, Marchetti Piero, Markell Mariana, Naicker Sarala, O'Connell Philip, Schnitzler Mark, Standl Eberhard, Torregosa Jose-Vicente, Uchida Kazuharu, Valantine Hannah, Villamil Federico, Vincenti Flavio, Wissing Martin
David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Clin Transplant. 2005 Jun;19(3):291-8. doi: 10.1111/j.1399-0012.2005.00359.x.
Although graft and patient survival after solid organ transplantation have improved markedly in recent years, transplant recipients continue to experience an increased prevalence of cardiovascular disease (CVD) compared with the general population. A number of factors are known to impact on the increased risk of CVD in this population, including hypertension, dyslipidemia and diabetes mellitus. Of these factors, new-onset diabetes after transplantation has been identified as one of the most important, being associated with reduced graft function and patient survival, and increased risk of graft loss. In 2003, International Consensus Guidelines on New-onset Diabetes after Transplantation were published, which aimed to establish a precise definition and diagnosis of the condition and recommend management strategies to reduce its occurrence and impact. These updated 2004 guidelines, developed in consultation with the International Diabetes Federation (IDF), extend the recommendations of the previous guidelines and encompass new-onset diabetes after kidney, liver and heart transplantation. It is hoped that adoption of these management approaches pre- and post-transplant will reduce individuals' risk of developing new-onset diabetes after transplantation as well as ameliorating the long-term impact of this serious complication.
尽管近年来实体器官移植后的移植物和患者存活率有了显著提高，但与普通人群相比，移植受者心血管疾病（CVD）的患病率仍持续上升。已知有多种因素会影响该人群患CVD风险的增加，包括高血压、血脂异常和糖尿病。在这些因素中，移植后新发糖尿病已被确定为最重要的因素之一，它与移植物功能减退、患者存活率降低以及移植物丢失风险增加有关。2003年，发布了《移植后新发糖尿病国际共识指南》，旨在对该病症建立精确的定义和诊断，并推荐管理策略以减少其发生和影响。这些2004年更新的指南是在与国际糖尿病联盟（IDF）协商后制定的，扩展了先前指南的建议，涵盖了肾、肝和心脏移植后的新发糖尿病。希望在移植前后采用这些管理方法将降低个体移植后发生新发糖尿病的风险，并减轻这一严重并发症的长期影响。
