Pieringer Herwig, Biesenbach Georg
2nd Department of Medicine, General Hospital Linz, Linz, Austria.
Clin Transplant. 2005 Jun;19(3):391-8. doi: 10.1111/j.1399-0012.2005.00360.x.
The influence of delayed kidney graft function on allograft outcome is described controversially in the literature. The aim of the study was to evaluate possible risk factors for delayed graft function (DGF) and investigate the impact of DGF on short- and long-term renal allograft function. Two groups were formed: the first one consisted of patients who gained immediate graft function (IGF) (n = 64) after transplantation and the second group included patients with DGF (n = 31; with at least one dialysis needed in first week after transplantation). The DGF group had a statistically significant longer duration on dialyses prior to transplantation (DGF 54 vs. IGF 33 months; p < 0.05), on average more frequently a re-transplantation (DGF 1.7 vs. IGF 1.3; p < 0.01), a longer re-anastomosis time (DGF 52.9 vs. 44.2 min; p < 0.01), a lower systolic (DGF 136 +/-24 mmHg vs. IGF 158 +/- 25; p < 0.001) and diastolic blood pressure (DGF 78 +/- 14 vs. IGF 89 +/- 16 mmHg; p < 0.01) at admission to the hospital and a higher serum (S)-creatinine at discharge (DGF 2.5 +/- 1.6 vs. IGF 1.6 +/- 0.4 mg/dL; p < 0.01). Prior to transplantation the DGF group had more often advanced vascular diseases (DGF 29.0 vs. IGF 12.5%; p < 0.01) and these patients incurred more frequently new ones during the next 3 yr after transplantation (DGF 22.6 vs. IGF 6.3%; p < 0.001). After 3 yr the graft survival tended to be lower in the DGF group (DGF 74.2 vs. IGF 84.4%; NS), but this difference was not statistically significant.
肾移植延迟功能对同种异体移植结果的影响在文献中的描述存在争议。本研究的目的是评估移植肾功能延迟（DGF）的可能危险因素，并研究DGF对肾移植短期和长期功能的影响。研究分为两组：第一组由移植后获得即时移植肾功能（IGF）的患者组成（n = 64），第二组包括发生DGF的患者（n = 31；移植后第一周至少需要进行一次透析）。DGF组在移植前的透析时间在统计学上显著更长（DGF组为54个月，IGF组为33个月；p < 0.05），再次移植的平均频率更高（DGF组为1.7次，IGF组为1.3次；p < 0.01），再次吻合时间更长（DGF组为52.9分钟，IGF组为44.2分钟；p < 0.01），入院时收缩压（DGF组为136±24 mmHg，IGF组为158±25 mmHg；p < 0.001）和舒张压更低（DGF组为78±14 mmHg，IGF组为89±16 mmHg；p < /span>0.01），出院时血清肌酐更高（DGF组为2.5±1.6 mg/dL，IGF组为1.6±0.4 mg/dL；p < 0.01）。移植前，DGF组更常出现晚期血管疾病（DGF组为29.0%，IGF组为12.5%；p < 0.01），并且这些患者在移植后的接下来3年中更频繁地出现新的血管疾病（DGF组为22.6%，IGF组为6.3%；p < 0.001）。3年后，DGF组的移植物存活率趋于较低（DGF组为74.2%，IGF组为84.4%；无统计学意义），但这种差异无统计学意义。
