Zhang Xin-jiang, Wang Wei, Yin Xiao-ping, Chang Li-ying, Xu Guang-run, Zhang Su-ming, Jiang Ya-ping, Fang Si-yu
Department of Neurology, Yangzhou The First People's Hospital, Yangzhou 225001, Jiangsu, China.
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2005 May;17(5):276-8.
To investigate the safety and effect of injecting heparin into hematoma on peri-hematoma edema and hematoma volume in pigs with intracerebral hemorrhage (ICH).
Thirteen sucking pigs were divided randomly into two groups: hemorrhage group, in which 2.5 ml arterial blood was injected into the right frontal lobe and heparin group, in which 0.2 ml of heparin was injected into the hematoma produced by the injection of 2.3 ml of blood into the similar site. The hematoma volume and peri-hematoma edema were determined by the sequences of T2* weighted image (T2*WI), fluid-attenuated inversion- recovery (FLAIR) image and diffusion weighted image (DWI) by 1.5 T magnetic resonance image (MRI) from 30-60 minutes afterwards to 24 hours. The peri-hematoma apparent diffusion coefficient (ADC) was compared with that of contralateral hemisphere, and the corresponding histologic changes were studied.
The average volume, shown by T2*WI at 24 hours, was significantly larger than that at 30-60 minutes after hematoma formation in hemorrhagic group [(5.29+/-0.98) cm3 vs. (3.09+/-0.38) cm3, P<0.01]. But there was no significant change in hematoma volume in hemorrhagic group from 30-60 minutes on to 24 hours [(2.21+/-0.28) cm3 vs. (2.33+/-0.30) cm3, P>0.05]. Both increased and decreased ADC were found around the hematoma in some animals of the heparin group compared with that of the contralateral hemisphere. On the other hand, in hemorrhagic group, only increased ADC could be found around the lesion, and there was no decreased ADC.
Injection of heparin into an intracerebral hematoma leads to enlargement of the hematoma and more marked peri-lesion edema. On ADC maps, enlargement of hematoma is attributed to the edema around the lesion leading to injury to the brain tissue.
探讨向脑出血（ICH）猪的血肿内注射肝素对血肿周围水肿及血肿体积的安全性和影响。
将13只乳猪随机分为两组：出血组，向右侧额叶注射2.5 ml动脉血；肝素组，向在相似部位注射2.3 ml血液所产生的血肿内注射0.2 ml肝素。在注射后30分钟至60分钟直至24小时期间，通过1.5 T磁共振成像（MRI）的T2加权成像（T2WI）、液体衰减反转恢复（FLAIR）成像和扩散加权成像（DWI）序列测定血肿体积和血肿周围水肿情况。将血肿周围表观扩散系数（ADC）与对侧半球进行比较，并研究相应的组织学变化。
出血组在血肿形成后24小时时，T2*WI显示的平均体积显著大于30分钟至60分钟时[（5.29±0.98）cm³ 对 （3.09±0.38）cm³，P<0.01]。但出血组从30分钟至60分钟到24小时血肿体积无显著变化[（2.21±0.28）cm³ 对 （2.33±0.30）cm³，P>0.05]。与对侧半球相比，肝素组部分动物血肿周围ADC有升高和降低情况。另一方面，出血组在病灶周围仅发现ADC升高，未发现ADC降低。
向脑内血肿注射肝素会导致血肿扩大及病灶周围水肿更明显。在ADC图上，血肿扩大归因于病灶周围水肿导致脑组织损伤。
