Melgire Manuela, Ragot Richard, Samson Séverine, Penney Trevor B, Meck Warren H, Pouthas Viviane
Unité de Neurosciences Cognitives et d'Imagerie Cérébrale, CNRS, UPR-640, Paris, France.
Brain Cogn. 2005 Jun;58(1):119-24. doi: 10.1016/j.bandc.2004.09.013. Epub 2004 Nov 30.
Patients with unilateral (left or right) medial temporal lobe lesions and normal control (NC) volunteers participated in two experiments, both using a duration bisection procedure. Experiment 1 assessed discrimination of auditory and visual signal durations ranging from 2 to 8 s, in the same test session. Patients and NC participants judged auditory signals as longer than equivalent duration visual signals. The difference between auditory and visual time discrimination was equivalent for the three groups, suggesting that a unilateral temporal lobe resection does not modulate the modality effect. To document interval-timing abilities after temporal lobe resection for different duration ranges, Experiment 2 investigated the discrimination of brief, 50-200 ms, auditory durations in the same patients. Overall, patients with right temporal lobe resection were found to have more variable duration judgments across both signal modality and duration range. These findings suggest the involvement of the right temporal lobe at the level of the decision process in temporal discriminations.
患有单侧（左侧或右侧）内侧颞叶病变的患者和正常对照（NC）志愿者参与了两项实验，两项实验均采用时长二等分程序。实验1在同一测试环节中评估了对时长范围为2至8秒的听觉和视觉信号的辨别能力。患者和NC参与者判断听觉信号的时长比时长相等的视觉信号更长。三组的听觉和视觉时间辨别差异相当，这表明单侧颞叶切除术不会调节模态效应。为了记录颞叶切除术后不同时长范围内的间隔计时能力，实验2研究了同一批患者对时长为50 - 200毫秒的简短听觉时长的辨别能力。总体而言，发现右侧颞叶切除的患者在信号模态和时长范围内的时长判断变化更大。这些发现表明右侧颞叶在时间辨别决策过程层面发挥作用。
