Madhok Ashish B, Chandrasekran A, Parnell Vincent, Gandhi Mysore, Chowdhury Devyani, Pahwa Savita
North Shore-Long Island Jewish Research Institute and Schneider Children's Hospital, North Shore-Long Island Jewish Health System, Manhasset, New York, USA.
Clin Diagn Lab Immunol. 2005 May;12(5):563-5. doi: 10.1128/CDLI.12.5.563-565.2005.
The human thymus is required for establishment of a T-cell pool in fetal life, but postnatal thymectomy is not known to cause immunodeficiency. T-cell emigration from thymus (thymic recent emigrants [TRECs]) is a continuous thymic-dependent process. We studied TREC levels pre- and post-partial thymectomy in children undergoing cardiac surgery. TRECs were quantitated by real-time PCR in peripheral blood lymphocytes of 24 children (0 to 12 years). TREC values were 47916 +/- 9271 pre-partial thymectomy and 33157 +/- 8479 post-partial thymectomy in 11 paired patients (P = 0.014). Interval between pre- and post-partial thymectomy was 8.8 days +/- 5.8 days. Another group of 8 children had 30384 +/- 9748 TRECs 16 days to 6 years post-partial thymectomy. There was a significant drop in TREC values post-partial thymectomy in the immediate postoperative period compared to prethymectomy TREC levels. While decreased thymic output may persist, the long-term implications were not evaluated in this patient population.
人类胸腺对于胎儿期T细胞库的建立是必需的，但出生后胸腺切除并不被认为会导致免疫缺陷。T细胞从胸腺迁出（胸腺近期迁出细胞 [TRECs]）是一个持续的依赖胸腺的过程。我们研究了接受心脏手术的儿童在部分胸腺切除术前和术后的TREC水平。通过实时PCR对24名儿童（0至12岁）外周血淋巴细胞中的TRECs进行定量。在11对配对患者中，部分胸腺切除术前TREC值为47916±9271，术后为33157±8479（P = 0.014）。部分胸腺切除术前和术后的间隔时间为8.8天±5.8天。另一组8名儿童在部分胸腺切除术后16天至6年时TRECs为30384±9748。与胸腺切除术前TREC水平相比，部分胸腺切除术后即刻术后期间TREC值有显著下降。虽然胸腺输出减少可能持续存在，但在该患者群体中未评估其长期影响。
