Jamieson B D, Douek D C, Killian S, Hultin L E, Scripture-Adams D D, Giorgi J V, Marelli D, Koup R A, Zack J A
Department of Medicine, UCLA School of Medicine and Jonsson Comprehensive Cancer Center, Los Angeles, California 90095-1678, USA.
Immunity. 1999 May;10(5):569-75. doi: 10.1016/s1074-7613(00)80056-4.
Reconstituting the immune response will be critical for the survival of HIV-infected individuals once viral load is brought under control. While the adult thymus was previously thought to be relatively inactive, new data suggest it may play a role in T cell reconstitution. We examined thymopoiesis in adults up to 56 years of age and found active T cell receptor (TCR) rearrangement, generating a diverse TCR Vbeta repertoire. The resulting thymocytes are functional and are capable of responding to costimulatory signals. These data demonstrate that the adult thymus remains active late in life and contributes functional T cells to the peripheral lymphoid pool.
一旦病毒载量得到控制，重建免疫反应对于HIV感染者的生存至关重要。虽然以前认为成人胸腺相对不活跃，但新数据表明它可能在T细胞重建中发挥作用。我们研究了56岁以下成年人的胸腺生成，发现有活跃的T细胞受体（TCR）重排，产生了多样化的TCR Vβ库。由此产生的胸腺细胞具有功能，能够对共刺激信号作出反应。这些数据表明，成人胸腺在生命后期仍保持活跃，并为外周淋巴池贡献功能性T细胞。
