Shurtz-Swirski R, Cohen Y, Barnea E R
University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Camden.
Hum Reprod. 1992 Mar;7(3):300-4. doi: 10.1093/oxfordjournals.humrep.a137639.
There is great concern regarding maternal exposure to medications, especially in the first trimester of pregnancy because of the possible teratogenic effects. In the present study we have examined the consequences of maternal drug exposure in vivo upon placental secretion patterns of human chorionic gonadotrophin (HCG) and the relationship between the embryo and placenta in vitro. This was examined in samples obtained from various drug-exposed women following elective pregnancy termination at 8-9 weeks. The patterns of HCG secretion in superfused placental explants were different from those seen in control explants (without use of any medication). This was shown by changes in the pulse pattern and pulse frequency. In addition, the exposure of placental explants to various embryonic tissues modified HCG secretion in static cultures. In superfusion, co-perfusion with embryonic spinal cord tissue increased HCG secretion as opposed to that seen in similar incubations made with embryonic spinal cord tissue obtained from healthy women. Thus, our data suggest that maternal drug exposure alters both spontaneous hormone secretion by the placenta and the recently described embryo--placental relationship in vitro.
人们非常关注孕期母亲接触药物的情况，尤其是在妊娠头三个月，因为可能存在致畸作用。在本研究中，我们研究了孕期母亲体内接触药物对人绒毛膜促性腺激素（HCG）胎盘分泌模式的影响，以及体外胚胎与胎盘之间的关系。这是在8 - 9周选择性终止妊娠后从各种接触药物的女性获取的样本中进行研究的。体外灌注的胎盘外植体中HCG的分泌模式与对照外植体（未使用任何药物）不同。这通过脉冲模式和脉冲频率的变化得以体现。此外，在静态培养中，胎盘外植体与各种胚胎组织接触会改变HCG的分泌。在灌注实验中，与来自健康女性的胚胎脊髓组织共同灌注时，胚胎脊髓组织会增加HCG的分泌，而与来自接触药物女性的胚胎脊髓组织在类似培养条件下的情况相反。因此，我们的数据表明，孕期母亲接触药物会改变胎盘自发分泌激素的情况以及最近所描述的体外胚胎 - 胎盘关系。
