Hettiarachchi Gardhi H C M, Reddy Malireddy K, Sopory Sudhir K, Chattopadhyay Sudip
National Center for Plant Genome Research, JNU Campus, PO Box 10531, New Delhi, 110067, India.
Plant Cell Physiol. 2005 Jul;46(7):1154-60. doi: 10.1093/pcp/pci114. Epub 2005 May 6.
Although abiotic stress affects plant growth and development, demonstration of its direct effect on regulation of the components of the DNA replication machinery is largely unknown. In this work, we demonstrate that the expression of TOP2 (encoding topoisomerase II) is up-regulated by various abiotic stresses including salinity and low temperature, and phytohormones such as ABA (abscisic acid) and SA (salicylic acid). Transgenic studies with different deletion versions of the TOP2 promoter in tobacco define several promoter determinants responsible for specific abiotic stress responsiveness. Taken together, these results demonstrate a direct involvement of stress in the transcriptional regulation of TOP2.
