Ness Timothy J, Powell-Boone Tykeysha, Cannon Ronda, Lloyd L Keith, Fillingim Roger B
Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
J Urol. 2005 Jun;173(6):1983-7. doi: 10.1097/01.ju.0000158452.15915.e2.
We quantified differences in somatic and visceral sensation in healthy subjects and subjects with interstitial cystitis (IC).
A total of 13 subjects with IC and 13 healthy subjects answered psychological questionnaires and underwent psychophysical testing of thermal and pressure thresholds for sensation as well as the ischemic forearm test of pain tolerance. A subset of subjects also underwent bladder sensory testing with the determination of 3 consecutive cystometrograms. Ratings of intensity and unpleasantness were determined.
Subjects with IC were significantly more sensitive to deep tissue measures of sensation related to pressure, ischemia and bladder than healthy subjects. Cutaneous thermal pain measures were similar in the 2 groups. Psychological measures indicated higher reactivity in subjects with IC.
Similar to other visceral pain disorders, such as irritable bowel syndrome, hypersensitivity to somatic stimuli was noted in subjects with IC. This suggests altered central mechanisms in the processing of sensory events from the bladder.
我们对健康受试者和间质性膀胱炎（IC）患者的躯体感觉和内脏感觉差异进行了量化。
总共13名IC患者和13名健康受试者回答了心理问卷，并接受了感觉热阈值和压力阈值的心理物理学测试以及疼痛耐受性的缺血性前臂试验。一部分受试者还进行了膀胱感觉测试，测定了连续3次膀胱压力图。确定了强度和不适感评分。
与健康受试者相比，IC患者对与压力、缺血和膀胱相关的深部组织感觉测量更为敏感。两组的皮肤热痛测量结果相似。心理测量表明IC患者的反应性更高。
与其他内脏疼痛疾病（如肠易激综合征）相似，IC患者存在对躯体刺激的超敏反应。这表明膀胱感觉事件处理过程中的中枢机制发生了改变。
