感染人类免疫缺陷病毒（HIV）且患有感觉神经病变个体中的抗硫脂抗体

Anti-sulfatide antibodies in HIV-infected individuals with sensory neuropathy.

作者信息

Lopate G, Pestronk A, Evans S, Li L, Clifford D

机构信息

Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.

出版信息

Neurology. 2005 May 10;64(9):1632-4. doi: 10.1212/01.WNL.0000160394.77818.AD.

DOI:10.1212/01.WNL.0000160394.77818.AD

PMID:15883332

Abstract

We used ELISA to estimate the prevalence of anti-sulfatide antibodies in HIV-infected individuals with distal sensory neuropathy (DSP) and compared the results with the prevalence in HIV-infected individuals without DSP and in individuals with neuropathy who are not infected with HIV. We found that 36% of HIV+/DSP+ individuals had immunoglobulin (Ig) G anti-sulfatide antibody titers greater than 1,500, whereas IgG anti-sulfatide antibodies were rarely found in HIV+/DSP- or HIV-/DSP+ patients.

摘要

我们使用酶联免疫吸附测定法（ELISA）来评估患有远端感觉神经病变（DSP）的HIV感染者中抗硫酸脑苷脂抗体的流行情况，并将结果与未患DSP的HIV感染者以及未感染HIV的神经病变患者中的流行情况进行比较。我们发现，36%的HIV+/DSP+个体的免疫球蛋白（Ig）G抗硫酸脑苷脂抗体滴度大于1500，而在HIV+/DSP-或HIV-/DSP+患者中很少发现IgG抗硫酸脑苷脂抗体。