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骨质疏松症:微量营养素的作用

Osteoporosis: the role of micronutrients.

作者信息

Nieves Jeri W

机构信息

Clinical Research and Regional Bone Centers, Helen Hayes Hospital, West Haverstraw, NY, USA.

出版信息

Am J Clin Nutr. 2005 May;81(5):1232S-1239S. doi: 10.1093/ajcn/81.5.1232.

Abstract

Osteoporosis and low bone mass are currently estimated to be a major public health threat. Adequate nutrition plays a major role in the prevention and treatment of osteoporosis; the micronutrients of greatest importance are calcium and vitamin D. Calcium has been shown to have beneficial effects on bone mass at all ages, although the results are not always consistent. Higher doses than the current US recommendation (600 IU) of vitamin D in the elderly (age > or = 65 y) may actually be required for optimal bone health (800-1000 IU/d). The elderly can clearly benefit from increased vitamin D intakes; however, the potential importance of vitamin D in peak bone mass is just being investigated. Vitamin D has been related to falls, with supplementation reducing the number of falls. There are clear fracture benefits demonstrated in randomized clinical trials of calcium and vitamin D supplementation. The other micronutrient needs for optimizing bone health can be easily met by a healthy diet that is high in fruits and vegetables to ensure adequate intakes for magnesium, potassium, vitamin C, vitamin K, and other potentially important nutrients. Healthcare professionals need to be aware of the importance of adequate calcium and vitamin D intakes (easily monitored by serum 25(OH)D) for optimal bone health, as well as the prevention of falls and fractures. In addition, a healthy diet that includes 5 servings a day of fruits and vegetables should optimize the intake of micronutrients required for bone health.

摘要

目前估计骨质疏松症和低骨量是一项重大的公共卫生威胁。充足的营养在骨质疏松症的预防和治疗中起着主要作用;最重要的微量营养素是钙和维生素D。尽管结果并不总是一致,但已表明钙对各年龄段的骨量都有有益影响。对于老年人(年龄≥65岁),为达到最佳骨骼健康状态,可能实际上需要高于美国当前推荐量(600国际单位)的维生素D(800 - 1000国际单位/天)。老年人显然能从增加维生素D摄入量中获益;然而,维生素D在峰值骨量中的潜在重要性才刚刚开始研究。维生素D与跌倒有关,补充维生素D可减少跌倒次数。在钙和维生素D补充剂的随机临床试验中,已证明对骨折有明显益处。通过富含水果和蔬菜的健康饮食,可轻松满足优化骨骼健康所需的其他微量营养素需求,以确保摄入足够的镁、钾、维生素C、维生素K及其他可能重要的营养素。医疗保健专业人员需要意识到充足的钙和维生素D摄入量(可通过血清25(OH)D轻松监测)对于最佳骨骼健康以及预防跌倒和骨折的重要性。此外,每天包含五份水果和蔬菜的健康饮食应能优化骨骼健康所需微量营养素的摄入。

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