Bischoff-Ferrari Heike A, Staehelin Hannes B
Centre on Aging and Mobility, University Hospital Zurich, Zurich, Switzerland.
Int J Vitam Nutr Res. 2008 Dec;78(6):286-92. doi: 10.1024/0300-9831.78.6.286.
We review the potential of vitamin D for the prevention of falls and fractures. Evidence from randomized-controlled trials will be reviewed for both endpoints, as well as epidemiologic data that correlates higher 25-hydroxyvitamin D status with better bone and muscle health. This review summarizes the compelling dual benefit of vitamin D on bone and muscle health, a concept that is unique and important for optimal fracture prevention at higher age. We will review sources of vitamin D and calcium and also outline why calcium supplementation alone may not contribute to fracture prevention at higher age. This review concludes that vitamin D at a dose of at least 800 IU per day should be provided to all postmenopausal women and everybody starting at age 60 for optimal bone and muscle health. In combination with a vitamin D supplement, dairy products may be an optimal source of calcium at higher age as milk provides both calcium and protein.
我们综述了维生素D预防跌倒和骨折的潜力。将对随机对照试验针对这两个终点的证据以及将较高的25-羟维生素D水平与更好的骨骼和肌肉健康相关联的流行病学数据进行综述。本综述总结了维生素D对骨骼和肌肉健康具有令人信服的双重益处，这一概念对于高龄人群的最佳骨折预防而言是独特且重要的。我们将回顾维生素D和钙的来源，并概述为何仅补充钙可能对高龄人群预防骨折并无助益。本综述得出结论，为了实现最佳的骨骼和肌肉健康，应向所有绝经后女性以及所有60岁及以上的人群提供每日至少800国际单位剂量的维生素D。与维生素D补充剂相结合，乳制品可能是高龄人群钙的最佳来源，因为牛奶既提供钙又提供蛋白质。
