Thobois Stéphane, Delamarre-Damier Florence, Derkinderen Pascal
Service de Neurologie, Hôpital Neurologique Pierre Wertheimer, Lyon, France.
Clin Neurol Neurosurg. 2005 Jun;107(4):269-81. doi: 10.1016/j.clineuro.2005.02.002.
Levodopa remains the most effective treatment for Parkinson's disease (PD). However, the use of this drug is complicated by several adverse effects, in particular motor fluctuations and dyskinesias. Drugs providing more continuous dopaminergic stimulation and surgical approaches, such as deep-brain stimulation, have an important ameliorative effect on these problems. Despite these advances, the progression of the disease remains unaffected and strategies that slow or stop the neurodegenerative process are currently not available. Nevertheless, several compounds or surgical procedures are candidates for being neuroprotective and some of them are under evaluation.
左旋多巴仍然是治疗帕金森病（PD）最有效的药物。然而，使用这种药物会出现几种不良反应，尤其是运动波动和异动症，这使得治疗变得复杂。能提供更持续多巴胺能刺激的药物以及手术方法，如深部脑刺激，对这些问题有重要的改善作用。尽管有这些进展，但疾病的进展仍未得到控制，目前还没有减缓或阻止神经退行性过程的策略。不过，有几种化合物或手术方法有望具有神经保护作用，其中一些正在评估中。
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