晚期帕金森病的日间异动症可通过双侧丘脑底核或苍白球内侧部脑深部电刺激得以消除。
End of day dyskinesia in advanced Parkinson's disease can be eliminated by bilateral subthalamic nucleus or globus pallidus deep brain stimulation.
作者信息
Apetauerova Diana, Ryan R Kevin, Ro Susie I, Arle Jeffrey, Shils Jay, Papavassiliou Efstathios, Tarsy Daniel
机构信息
Department of Neurology, Lahey Clinic Medical Center, Burlington, Massachusetts, USA.
出版信息
Mov Disord. 2006 Aug;21(8):1277-9. doi: 10.1002/mds.20896.
We report the therapeutic effects of deep brain stimulation (DBS) in 2 patients with Parkinson's disease (PD) with severe end of dose dyskinesia that was resistant to medical therapy. In both patients, severe, end of day ballistic dyskinesias occurred when the last levodopa dose of the day was wearing off. Globus pallidus (GPi) DBS in 1 case and subthalamic (STN) DBS in the second case produced full resolution of end of day dyskinesia.
我们报告了深部脑刺激（DBS）对2例患有严重的剂末异动症且药物治疗无效的帕金森病（PD）患者的治疗效果。在这2例患者中，当日最后一剂左旋多巴药效消退时均出现严重的日间弹道式异动症。1例患者接受苍白球内侧部（GPi）DBS治疗，另1例患者接受丘脑底核（STN）DBS治疗，二者的日间异动症均完全缓解。
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