活体供体远端胰腺切除及胰岛同种异体移植后的胰岛素非依赖状态

Insulin independence after living-donor distal pancreatectomy and islet allotransplantation.

作者信息

Matsumoto Shinichi, Okitsu Teru, Iwanaga Yasuhiro, Noguchi Hirofumi, Nagata Hideo, Yonekawa Yukihide, Yamada Yuichiro, Fukuda Kazuhito, Tsukiyama Katsushi, Suzuki Haruhiko, Kawasaki Yukiko, Shimodaira Makiko, Matsuoka Keiko, Shibata Toshiya, Kasai Yasunari, Maekawa Taira, Shapiro James, Tanaka Koichi

机构信息

Kyoto University Hospital Transplantation Unit, Kyoto Japan.

出版信息

Lancet. 2005;365(9471):1642-4. doi: 10.1016/s0140-6736(05)66383-0.

DOI:10.1016/s0140-6736(05)66383-0

PMID:15889479

Abstract

Rising demand for islet transplantation will lead to severe donor shortage in the near future, especially in countries where cadaveric organ donation is scarce. We undertook a successful transplantation of living-donor islets for unstable diabetes. The recipient was a 27-year-old woman who had had brittle, insulin-dependent diabetes mellitus for 12 years. The donor, who was a healthy 56-year-old woman and mother of the recipient, underwent a distal pancreatectomy. After isolation, 408 114 islet equivalents were transplanted immediately. The transplants functioned immediately and the recipient became insulin-independent 22 days after the operation. The donor had no complications and both women showed healthy glucose tolerance. Transplantation of living-donor islets from the distal pancreas can be sufficient to reverse brittle diabetes.

摘要

对胰岛移植需求的不断增加将在不久的将来导致严重的供体短缺，尤其是在尸体器官捐赠稀缺的国家。我们成功地进行了活体供体胰岛移植治疗不稳定型糖尿病。受者是一名27岁的女性，患脆性胰岛素依赖型糖尿病12年。供者是一位健康的56岁女性，为受者的母亲，接受了远端胰腺切除术。分离后，立即移植了408114个胰岛当量。移植立即发挥作用，受者在术后22天不再依赖胰岛素。供者无并发症，两名女性均表现出健康的糖耐量。来自远端胰腺的活体供体胰岛移植足以逆转脆性糖尿病。