Pancreatic Islet Transplantation Project, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Department of Diabetes, Endocrinology and Metabolism, National Center for Global health and Medicine, Tokyo, Japan.
J Diabetes Investig. 2022 Apr;13(4):741-745. doi: 10.1111/jdi.13715. Epub 2021 Dec 17.
Here, we report a case of allogeneic islet transplantation in Japan. A 48-year-old man received intraportal islet transplantation (5,945 islet equivalent/kg), and stabilization of blood glucose levels and suppression of hypoglycemia were achieved. In the present case, we used our original assessment method to detect the responses of the recipient's T cells to islet autoantigens over time to monitor cellular autoimmunity. Other markers could not predict graft dysfunction in advance, but our method detected the activation of islet antigen-specific CD8 T-cell responses before the deterioration of pancreatic β-cell function, indicating the possibility of the non-invasive detection of pancreatic β-cell damage due to recurrent autoimmunity.
这里，我们报告了一例在日本进行的同种异体胰岛移植。一名 48 岁男性接受了门静脉内胰岛移植（5945 胰岛当量/kg），实现了血糖水平的稳定和低血糖的抑制。在本病例中，我们使用我们的原始评估方法来检测受者 T 细胞对胰岛自身抗原的反应随时间的变化，以监测细胞自身免疫。其他标志物不能提前预测移植物功能障碍，但我们的方法在胰腺β细胞功能恶化之前检测到胰岛抗原特异性 CD8 T 细胞反应的激活，表明有可能非侵入性地检测由于自身免疫复发导致的胰腺β细胞损伤。
