伊朗乳腺癌女性中α和β肿瘤坏死因子（TNF-α和TNF-β）以及γ干扰素（IFN-γ）基因的多态性。
Polymorphism in the genes of alpha and beta tumor necrosis factors (TNF-alpha and TNF-beta) and gamma interferon (IFN-gamma) among Iranian women with breast cancer.
作者信息
Kamali-Sarvestani Eskandar, Merat Ahmad, Talei Abdol-Rasoul
机构信息
Department of Immunology, Medical School, Shiraz University of Medical Sciences, PO Box 71345-1798, Shiraz, Iran.
出版信息
Cancer Lett. 2005 Jun 1;223(1):113-9. doi: 10.1016/j.canlet.2004.09.025.
The association of the polymorphism in the genes of TNF-alpha, TNF-beta and IFN-gamma with breast cancer was investigated in the present study. There were no differences in the TNF-alpha and TNF-beta alleles and genotypes frequencies between breast cancer patients (n=223) and control subjects (n=267). The correlations between TNFA or TNFB alleles or genotypes and clinicopathological indices were also insignificant. However, the frequency of IFN-gamma+874 T/T genotype was significantly higher in breast cancer patients compared to those of controls (P<0.002; OR=2.03, 95% CI=1.28-3.2) which indicates that Iranian women carrying the IFN-gamma+874 T/T genotype may be exposed to an increased risk of breast cancer development.
本研究调查了肿瘤坏死因子-α（TNF-α）、肿瘤坏死因子-β（TNF-β）和干扰素-γ（IFN-γ）基因多态性与乳腺癌的关联。乳腺癌患者（n = 223）和对照受试者（n = 267）之间的TNF-α和TNF-β等位基因及基因型频率无差异。TNFA或TNFB等位基因或基因型与临床病理指标之间的相关性也不显著。然而，与对照组相比，乳腺癌患者中干扰素-γ +874 T/T基因型的频率显著更高（P < 0.002；比值比=2.03，95%置信区间=1.28 - 3.2），这表明携带干扰素-γ +874 T/T基因型的伊朗女性可能面临患乳腺癌风险增加的情况。
Zotero 插件