Toll样受体信号传导在体内抑制乙型肝炎病毒复制。
Toll-like receptor signaling inhibits hepatitis B virus replication in vivo.
作者信息
Isogawa Masanori, Robek Michael D, Furuichi Yoshihiro, Chisari Francis V
机构信息
Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
出版信息
J Virol. 2005 Jun;79(11):7269-72. doi: 10.1128/JVI.79.11.7269-7272.2005.
Abstract
Toll-like receptors (TLR) play a key role in innate immunity. To examine the ability of diverse TLRs to modulate hepatitis B virus (HBV) replication, HBV transgenic mice received a single intravenous injection of ligands specific for TLR2, TLR3, TLR4, TLR5, TLR7, and TLR9. All of the ligands except for TLR2 inhibited HBV replication in the liver noncytopathically within 24 h in a alpha/beta interferon-dependent manner. The ability of these TLR ligands to induce antiviral cytokines at the site of HBV replication suggests that TLR activation could represent a powerful and novel therapeutic strategy for the treatment of chronic HBV infection.
摘要
Toll样受体（TLR）在天然免疫中起关键作用。为了检测不同TLR调节乙型肝炎病毒（HBV）复制的能力，给HBV转基因小鼠单次静脉注射针对TLR2、TLR3、TLR4、TLR5、TLR7和TLR9的配体。除TLR2配体外，所有配体均在24小时内以α/β干扰素依赖的方式在肝脏中以非细胞病变的方式抑制HBV复制。这些TLR配体在HBV复制部位诱导抗病毒细胞因子的能力表明，TLR激活可能是治疗慢性HBV感染的一种强大而新颖的治疗策略。
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