Goldenberg Robert L, Goepfert Alice R, Ramsey Patrick S
The Center for Research in Women's Health, University of Alabama at Birmingham, USA.
Am J Obstet Gynecol. 2005 May;192(5 Suppl):S36-46. doi: 10.1016/j.ajog.2005.02.015.
The prediction of preterm birth may be important (1) to initiate risk specific treatment; (2) to define a population that is at risk in which to study a particular treatment; or (3) to better understand the pathways that lead to preterm birth. Biologic fluids that have been used as sources for tests include serum, plasma, amniotic fluid, urine, vaginal and cervical secretions, saliva, and even periodontal fluid. We discuss the types of substances that are found in body fluids (eg, organisms, cytokines, enzymes, hormones) that have been studied as predictors of preterm birth, the fluids in which they are found, and issues that are related to the timing of the test, the cost, and the ease of fluid collection and processing. We emphasize that a test for any of these substances should not be introduced into clinical practice until the use of the test, which is followed by an appropriate intervention, leads to a reduction in preterm birth.
早产预测可能很重要，原因如下：（1）启动针对特定风险的治疗；（2）确定处于风险中的人群，以便在其中研究特定治疗方法；或者（3）更好地理解导致早产的途径。用作检测来源的生物液体包括血清、血浆、羊水、尿液、阴道和宫颈分泌物、唾液，甚至牙周液。我们讨论了在体液中发现的物质类型（如微生物、细胞因子、酶、激素），这些物质已被研究作为早产的预测指标，它们所在的体液，以及与检测时间、成本、体液采集和处理的难易程度相关的问题。我们强调，在使用这些物质中的任何一种进行检测并随后进行适当干预导致早产减少之前，不应将其引入临床实践。
