芽殖酵母和果蝇中的表观遗传沉默机制：路径不同，目标相同。
Epigenetic silencing mechanisms in budding yeast and fruit fly: different paths, same destinations.
作者信息
Pirrotta Vincenzo, Gross David S
机构信息
Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA.
出版信息
Mol Cell. 2005 May 13;18(4):395-8. doi: 10.1016/j.molcel.2005.04.013.
Transcriptional silencing in budding yeast and fruit fly is mediated by fundamentally unrelated proteins that assemble very different chromatin structures. Surprisingly, the repressive mechanisms evolved from these very different materials have similar features, including an epigenetic mode of inheritance and a block to transcription based on interference with the assembly or function of the promoter complex rather than with the binding of gene-specific activators.
出芽酵母和果蝇中的转录沉默是由根本不相关的蛋白质介导的，这些蛋白质组装出非常不同的染色质结构。令人惊讶的是，从这些截然不同的物质进化而来的抑制机制具有相似的特征，包括表观遗传的遗传模式以及基于干扰启动子复合物的组装或功能而非基因特异性激活剂的结合来阻断转录。
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