Gudmundsson Gunnar, Gislason Thorarinn, Janson Christer, Lindberg Eva, Suppli Ulrik Charlotte, Brøndum Eva, Nieminen Markku M, Aine Tiina, Hallin Runa, Bakke Per
Department of Respiratory Medicine and Allergology, Landspitali University Hospital, E-7 Fossvogur, IS-108 Reykjavik, Iceland.
Respir Med. 2006 Jan;100(1):87-93. doi: 10.1016/j.rmed.2005.04.003.
Patients with chronic obstructive pulmonary disease (COPD) often report anxiety, depression and poor health status, not least if they experience repeated hospitalisations due to acute exacerbations. The aim of this study was to analyse the interrelationships between health status, anxiety, depression and physical status in COPD patients being discharged after hospitalisation. This was a prospective study of 416 patients in five university hospitals in each of the Nordic countries. Data included demographic information, lung function and co-morbidity. The Hospital Anxiety and Depression Scale and St. George's Respiratory Questionnaire (SGRQ) were applied to all patients. Both anxiety and depression were common among these patients. Anxiety was more common in women than in men (47% vs. 34%, P=0.009) and current smokers had a higher prevalence of both anxiety (54% vs. 37%) and depression (43% vs. 23%) than non-smokers (P<0.01). In general, the studied COPD patients had poor health status, especially those with anxiety, depression or both. Psychological status was independently related to all dimensions of SGRQ. Higher GOLD stages were significantly associated with increasing impairment in health status. In conclusion this multicentre study showed that anxiety and depression are common in patients with COPD, and, furthermore, that patients with psychological disorders have poor health status. Screening for depression and anxiety may help to identify patients with poor quality of life and an urgent need for intervention in order to improve their health status.
慢性阻塞性肺疾病(COPD)患者常报告有焦虑、抑郁和健康状况不佳的情况,尤其是那些因急性加重而反复住院的患者。本研究的目的是分析住院后出院的COPD患者的健康状况、焦虑、抑郁和身体状况之间的相互关系。这是一项对北欧每个国家五所大学医院的416名患者进行的前瞻性研究。数据包括人口统计学信息、肺功能和合并症。对所有患者应用医院焦虑抑郁量表和圣乔治呼吸问卷(SGRQ)。焦虑和抑郁在这些患者中都很常见。女性焦虑比男性更常见(47%对34%,P = 0.009),与非吸烟者相比,当前吸烟者的焦虑(54%对37%)和抑郁(43%对23%)患病率更高(P < 0.01)。总体而言,所研究的COPD患者健康状况不佳,尤其是那些有焦虑、抑郁或两者皆有的患者。心理状态与SGRQ的所有维度独立相关。较高的慢性阻塞性肺疾病全球倡议(GOLD)分级与健康状况损害增加显著相关。总之,这项多中心研究表明,焦虑和抑郁在COPD患者中很常见,此外,有心理障碍的患者健康状况不佳。筛查抑郁和焦虑可能有助于识别生活质量差且急需干预以改善其健康状况的患者。