Mordenti J, Rescigno A
Department of Pharmacokinetics, Genentech Inc., South San Francisco, California 94080.
Pharm Res. 1992 Jan;9(1):17-25. doi: 10.1023/a:1018915307554.
General solutions for exist time, permanence time, dilution factor, and volume of distribution at steady state are derived for compartmental and noncompartmental systems. These derivations require that the systems are linear and state-determined. Unique values for these parameters cannot be determined when the site of elimination is not known; in this case the parameters can be defined by a range. Interpretation of this range and its significance and use in clinical situations are illustrated with two examples.
推导了房室系统和非房室系统中稳态存在时间、持续时间、稀释因子和分布容积的一般解。这些推导要求系统是线性的且状态确定的。当消除部位未知时，无法确定这些参数的唯一值；在这种情况下，参数可以用一个范围来定义。通过两个例子说明了该范围的解释及其在临床情况中的意义和用途。
