房室分析及其在药代动力学中的多种应用。
Compartmental analysis and its manifold applications to pharmacokinetics.
出版信息
AAPS J. 2010 Mar;12(1):61-72. doi: 10.1208/s12248-009-9160-x. Epub 2009 Nov 25.
Abstract
In this paper, I show how the concept of compartment evolved from the simple dilution of a substance in a physiological volume to its distribution in a network of interconnected spaces. The differential equations describing the fate of a substance in a living being can be solved, qualitatively and quantitatively, with the help of a number of mathematical techniques. A number of parameters of pharmacokinetic interest can be computed from the experimental data; often, the data available are not sufficient to determine some parameters, but it is possible to determine their range.
摘要
本文展示了 compartment 概念是如何从物质在生理体积中的简单稀释演变为其在相互连接的空间网络中的分布。借助于一系列数学技术，可以定性和定量地求解描述生物体内物质命运的微分方程。可以从实验数据中计算出许多药代动力学相关的参数；通常，可用的数据不足以确定某些参数，但可以确定其范围。
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本文引用的文献
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On the use of pharmacokinetic models.关于药代动力学模型的应用。
Phys Med Biol. 2004 Oct 7;49(19):4657-76. doi: 10.1088/0031-9155/49/19/014.
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Flow diagrams of multi-compartment systems.多室系统的流程图。
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Estimation of permanence time, exit time, dilution factor, and steady-state volume of distribution.估算滞留时间、消除时间、稀释因子和稳态分布容积。
Pharm Res. 1992 Jan;9(1):17-25. doi: 10.1023/a:1018915307554.
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