从大鼠肝微粒体中分离出的热稳定细胞生长抑制因子。
Heat stable cell growth inhibiting factor isolated from rat liver microsomes.
作者信息
Inaba K, Doi A, Nisida I
出版信息
Acta Med Okayama. 1979 Aug;33(4):213-7.
PMID:158948
Abstract
A heat stable cell growth inhibiting factor was isolated from rat liver microsomes by hot salt extraction, ethanol fractionation and the hot phenol method. The factor was contained in the RNA fraction (designated as mhRNA). mhRNA inhibited the growth of mouse fibroblast (L-929) cells at a relatively low concentration (55 microgram/ml of culture medium). The molecular weight of mhRNA was about 27,000 and the base composition was guanine and cytosine rich.
摘要
通过热盐提取、乙醇分级分离和热酚法从大鼠肝微粒体中分离出一种热稳定的细胞生长抑制因子。该因子存在于RNA组分中（命名为mhRNA）。mhRNA在相对较低的浓度（培养基中55微克/毫升）下就能抑制小鼠成纤维细胞（L-929）的生长。mhRNA的分子量约为27000，碱基组成富含鸟嘌呤和胞嘧啶。
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