Miyoshi A, Makino H, Hiramatsu M, Takahashi K, Yamane Y, Takahara J, Suzuki S, Ota Z, Ofuji T, Takehisa Y
Acta Med Okayama. 1979 Aug;33(4):305-14.
A 26-year-old female with Bartter's syndrome associated with Graves' disease is reported. This patient had a history of Graves' disease from the age of 22 and anti-thyroid drug (Methimazole) had been administered for 2 years. Thyroid function returned to normal but general fatigue and polyuria continued. Hypokalemia was diagnosed at 25 years of age and she was referred to our hospital for evaluation. Blood pressure was normal and laboratory data revealed normal thyroid function, hypokalemic alkalosis, high plasma renin activity and high plasma aldosterone concentration. She showed normal pressor sensitivity to norepinephrine infusion, grossly diminished pressor sensitivity to exogenous angiotensin II infusion compared with the normal. A renal biopsy specimen showed juxtaglomerular cell hyperplasia. Electron microscopy confirmed lacis cell (agranular cell) proliferation.
报告了一名患有巴特综合征并伴有格雷夫斯病的26岁女性。该患者自22岁起患有格雷夫斯病，曾服用抗甲状腺药物（甲巯咪唑）2年。甲状腺功能恢复正常，但全身乏力和多尿仍持续存在。25岁时诊断为低钾血症，她被转诊至我院进行评估。血压正常，实验室检查结果显示甲状腺功能正常、低钾性碱中毒、血浆肾素活性升高和血浆醛固酮浓度升高。她对去甲肾上腺素输注表现出正常的升压敏感性，与正常人相比，对外源性血管紧张素II输注的升压敏感性明显降低。肾活检标本显示肾小球旁细胞增生。电子显微镜检查证实了球外系膜细胞（无颗粒细胞）增殖。
