Peters Bjoern, Sidney John, Bourne Phil, Bui Huynh-Hoa, Buus Soeren, Doh Grace, Fleri Ward, Kronenberg Mitch, Kubo Ralph, Lund Ole, Nemazee David, Ponomarenko Julia V, Sathiamurthy Muthu, Schoenberger Stephen P, Stewart Scott, Surko Pamela, Way Scott, Wilson Steve, Sette Alessandro
La Jolla Institute of Allergy and Immunology, 3030 Bunker Hill Street, Suite 326, San Diego, CA 92109, USA.
Immunogenetics. 2005 Jun;57(5):326-36. doi: 10.1007/s00251-005-0803-5. Epub 2005 May 14.
Epitopes are defined as parts of antigens interacting with receptors of the immune system. Knowledge about their intrinsic structure and how they affect the immune response is required to continue development of techniques that detect, monitor, and fight diseases. Their scientific importance is reflected in the vast amount of epitope-related information gathered, ranging from interactions between epitopes and major histocompatibility complex molecules determined by X-ray crystallography to clinical studies analyzing correlates of protection for epitope based vaccines. Our goal is to provide a central resource capable of capturing this information, allowing users to access and connect realms of knowledge that are currently separated and difficult to access. Here, we portray a new initiative, "The Immune Epitope Database and Analysis Resource." We describe how we plan to capture, structure, and store this information, what query interfaces we will make available to the public, and what additional predictive and analytical tools we will provide.
表位被定义为抗原中与免疫系统受体相互作用的部分。要继续开发检测、监测和对抗疾病的技术，就需要了解它们的内在结构以及它们如何影响免疫反应。它们的科学重要性体现在收集到的大量与表位相关的信息中，从通过X射线晶体学确定的表位与主要组织相容性复合体分子之间的相互作用，到分析基于表位的疫苗保护相关性的临床研究。我们的目标是提供一个能够收集这些信息的核心资源，让用户能够访问并连接目前相互分离且难以获取的知识领域。在此，我们介绍一项新计划，即“免疫表位数据库与分析资源”。我们描述了我们计划如何捕获、构建和存储这些信息，将向公众提供哪些查询界面，以及我们将提供哪些额外的预测和分析工具。
