Prieto Pilar, Moore Graham, Reader Steve
Department of Crop Genetics, John Innes Centre, Colney, Norwich, NR4 7UH, UK.
Theor Appl Genet. 2005 Aug;111(3):505-10. doi: 10.1007/s00122-005-2040-6. Epub 2005 May 14.
During early meiosis, chromosomes pair via their telomeres and centromeres. This pairing induces a conformational change which propagates from these regions along each chromosome, making the chromatin of the partners accessible for intimate pairing. In the present study, we show by exploiting wheat-rye hybrids that the signal is initiated in both the presence and absence of either the Ph1 or Ph2 locus. However, the chromatin change only continues to propagate through rye telomeric heterochromatin when Ph1 is absent. This failure to propagate the chromatin change through the rye heterochromatin in the absence of Ph2 correlates with a subsequent lack of wheat-rye chromosome association at metaphase I.
在减数分裂早期，染色体通过端粒和着丝粒配对。这种配对会引发一种构象变化，该变化从这些区域沿着每条染色体传播，使配对的染色质能够紧密配对。在本研究中，我们利用小麦 - 黑麦杂种表明，无论是否存在Ph1或Ph2位点，信号都会启动。然而，只有当Ph1不存在时，染色质变化才会继续通过黑麦端粒异染色质传播。在没有Ph2的情况下，染色质变化无法通过黑麦异染色质传播，这与随后在中期I缺乏小麦 - 黑麦染色体联会相关。
