环、手镯或按扣：SMC复合物的时尚替代品。
Rings, bracelet or snaps: fashionable alternatives for Smc complexes.
作者信息
Huang Catherine E, Milutinovich Mark, Koshland Douglas
机构信息
Department of Embryology, Carnegie Institution of Washington, 115 W. University Parkway, Baltimore, MD 21210, USA.
出版信息
Philos Trans R Soc Lond B Biol Sci. 2005 Mar 29;360(1455):537-42. doi: 10.1098/rstb.2004.1609.
The mechanism of higher order chromosome organization has eluded researchers for over 100 years. A breakthrough occurred with the discovery of multi-subunit protein complexes that contain a core of two molecules from the structural maintenance of chromosome (Smc) family. Smc complexes are important structural components of chromosome organization in diverse aspects of DNA metabolism, including sister chromatid cohesion, condensation, global gene repression, DNA repair and homologous recombination. In these different processes, Smc complexes may facilitate chromosome organization by tethering together two parts of the same or different chromatin strands. The mechanism of tethering by Smc complexes remains to be elucidated, but a number of intriguing topological alternatives are suggested by the unusual structural features of Smc complexes, including their large coiled-coil domains and ATPase activities. Distinguishing between these possibilities will require innovative new approaches.
100多年来，高阶染色体组织的机制一直让研究人员捉摸不透。随着多亚基蛋白复合物的发现，这一领域取得了突破，该复合物包含来自染色体结构维持（Smc）家族的两个分子组成的核心。Smc复合物是染色体组织的重要结构成分，在DNA代谢的多个方面发挥作用，包括姐妹染色单体黏连、凝聚、全局基因抑制、DNA修复和同源重组。在这些不同的过程中，Smc复合物可能通过将同一或不同染色质链的两个部分拴在一起，促进染色体组织。Smc复合物拴系的机制仍有待阐明，但Smc复合物不同寻常的结构特征，包括其大的卷曲螺旋结构域和ATP酶活性，提示了一些有趣的拓扑学可能性。区分这些可能性需要创新的新方法。
Zotero 插件