Dawson Deborah A, Grant Bridget F, Stinson Frederick S, Zhou Yuan
Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892-9304, USA.
Alcohol Clin Exp Res. 2005 May;29(5):844-54. doi: 10.1097/01.alc.0000164374.32229.a2.
The three consumption questions from the Alcohol Use Disorders Identification Test (AUDIT-C) are increasingly used as a screener for alcohol use disorders (AUDs) and risk drinking.
In a representative sample of US adults 18 years of age and older, AUDIT-C scores (derived from consumption questions embedded in a large national survey) were used to estimate sensitivity, specificity, and areas under receiver operator characteristic curves (AUROCs) for alcohol dependence, any AUD, and risk drinking. AUDs were defined according to DSM-IV criteria. For men, risk drinking was defined as consuming >14 drinks per week or >4 drinks in a single day at least once a month; for women, the weekly and daily limits were >7 drinks and >3 drinks, respectively. The derived AUDIT-C was evaluated among past-year drinkers (n = 26,946), within the total population (n = 43,093), in groups defined by age, sex, and race/ethnicity, and among pregnant women, persons attending an emergency room, and college students.
For past-year drinkers, the AUROCs for the derived AUDIT-C were 0.887 for alcohol dependence, 0.860 for any AUD, and 0.966 for risk drinking. Scores were higher in the total population, 0.931, 0.917, and 0.981, respectively. The derived AUDIT-C performed slightly better in screening for dependence among women than men. Screening for risk drinking was better among men, probably because the third AUDIT-C question directly mirrors one of the definitions of risk drinking for men but not for women. Performance in pregnant women, past-year emergency room patients, and college students was on a par with performance in the general population.
The derived AUDIT-C performs well in screening for AUDs and risk drinking. The use of variable cut points for men and women improves its sensitivity and specificity. Validation in a realistic screening situation, in which the AUDIT-C questions are asked as stand-alone and not embedded items, is a critical future step.
酒精使用障碍识别测试(AUDIT-C)中的三个饮酒问题越来越多地被用作酒精使用障碍(AUD)和危险饮酒的筛查工具。
在年龄≥18岁的美国成年人代表性样本中,使用AUDIT-C评分(源自一项大型全国性调查中的饮酒问题)来估计酒精依赖、任何AUD以及危险饮酒的敏感性、特异性和受试者工作特征曲线下面积(AUROC)。AUD根据《精神疾病诊断与统计手册》第四版(DSM-IV)标准进行定义。对于男性,危险饮酒定义为每周饮酒超过14杯或每月至少有一次单日饮酒超过4杯;对于女性,每周和单日的饮酒限量分别为超过7杯和超过3杯。在过去一年的饮酒者(n = 26,946)、总人口(n = 43,093)、按年龄、性别和种族/族裔定义的群体以及孕妇、急诊室就诊者和大学生中评估衍生的AUDIT-C。
对于过去一年的饮酒者,衍生的AUDIT-C用于酒精依赖的AUROC为0.887,用于任何AUD的为0.860,用于危险饮酒的为0.966。在总人口中的评分分别更高,为0.931、0.917和0.981。衍生的AUDIT-C在筛查女性的酒精依赖方面比男性表现稍好。在男性中筛查危险饮酒的效果更好,这可能是因为AUDIT-C的第三个问题直接反映了男性危险饮酒的定义之一,而不是女性的。孕妇、过去一年的急诊室患者和大学生中的表现与一般人群中的表现相当。
衍生的AUDIT-C在筛查AUD和危险饮酒方面表现良好。对男性和女性使用可变切点可提高其敏感性和特异性。在实际筛查情况下进行验证是未来的关键步骤,在这种情况下,AUDIT-C问题是作为独立问题而非嵌入项目来询问的。