Pauser Ursula, Kosmahl Markus, Kruslin Bozo, Klimstra David S, Klöppel Günter
Department of Pathology, University of Kiel, Michaelisstrasse 11, 24105 Kiel, Germany.
Am J Surg Pathol. 2005 Jun;29(6):797-800. doi: 10.1097/01.pas.0000157748.18591.d7.
Nonneoplastic tumor-like lesions ("pseudotumors") of the pancreas include cystic and noncystic varieties. We report on a solid and cystic tumor-like lesion of the pancreas that occurred in 2 adult patients. The lesions, located in the head and neck of the gland, respectively, were well demarcated and composed of cystic ductal structures embedded in focally inflamed stromal tissue. In addition, one of the lesions showed irregularly arranged but well-differentiated acini and small intralobular and interlobular ducts embedded in hypocellular, fibrotic tissue. Discrete islets were lacking, but immunohistochemical staining for chromogranin A revealed individual scattered endocrine cells evenly distributed between acinar and ductal cells. The surrounding pancreatic parenchyma did not show significant chronic pancreatitis. After tumor removal, the follow-up of the patients was uneventful. Because of the irregular arrangement of otherwise mature tissue components of the pancreas, the lesions were considered solid and cystic hamartomas. Their pathogenesis is so far unknown.
胰腺的非肿瘤性肿瘤样病变(“假瘤”)包括囊性和非囊性类型。我们报告了2例成年患者发生的胰腺实性和囊性肿瘤样病变。病变分别位于胰腺的头部和颈部,界限清楚,由嵌入局灶性炎症间质组织中的囊性导管结构组成。此外,其中一个病变显示腺泡排列不规则但分化良好,还有小的小叶内和小叶间导管嵌入细胞少的纤维化组织中。未见离散的胰岛,但嗜铬粒蛋白A免疫组化染色显示单个散在的内分泌细胞均匀分布于腺泡细胞和导管细胞之间。周围胰腺实质未显示明显的慢性胰腺炎。肿瘤切除后,患者的随访情况良好。由于胰腺其他成熟组织成分排列不规则,这些病变被认为是实性和囊性错构瘤。其发病机制目前尚不清楚。