与质子官能团兼容的催化对映选择性硫酯羟醛反应。
Catalytic enantioselective thioester aldol reactions that are compatible with protic functional groups.
作者信息
Magdziak Derek, Lalic Gojko, Lee Hong Myung, Fortner Kevin C, Aloise Allen D, Shair Matthew D
机构信息
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
出版信息
J Am Chem Soc. 2005 May 25;127(20):7284-5. doi: 10.1021/ja051759j.
PMID:15898756
Abstract
This communication reports highly enantioselective and diastereoselective methyl malonic acid half thioester (MeMAHT) aldol reactions that are compatible with protic functional groups and enolizable aldehydes, affording syn S-phenyl thiopropionates.
摘要
本通讯报道了高度对映选择性和非对映选择性的甲基丙二酸半硫酯（MeMAHT）羟醛反应，该反应与质子官能团和可烯醇化的醛兼容，可生成顺式S-苯基硫代丙酸酯。
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