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Arthritis Res Ther. 2005;7(3):111-3. doi: 10.1186/ar1746. Epub 2005 Mar 30.
2
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Increasing expression of substance P and calcitonin gene-related peptide in synovial tissue and fluid contribute to the progress of arthritis in developmental dysplasia of the hip.P物质和降钙素基因相关肽在发育性髋关节发育不良的滑膜组织和滑液中的表达增加，促进了关节炎的进展。
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本文引用的文献

1
Levels of gastrin-releasing peptide and substance P in synovial fluid and serum correlate with levels of cytokines in rheumatoid arthritis.类风湿关节炎患者滑液和血清中胃泌素释放肽及P物质的水平与细胞因子水平相关。
Arthritis Res Ther. 2005;7(3):R416-26. doi: 10.1186/ar1503. Epub 2005 Feb 7.
2
Role of cytokines in rheumatoid arthritis.细胞因子在类风湿关节炎中的作用。
Drug News Perspect. 1998 Aug;11(6):331-41. doi: 10.1358/dnp.1998.11.6.661380.
3
New drugs for rheumatoid arthritis.治疗类风湿性关节炎的新药。
N Engl J Med. 2004 Dec 16;351(25):2659-61; author reply 2659-61. doi: 10.1056/NEJM200412163512522.
4
Emerging biological therapies in rheumatoid arthritis.类风湿关节炎中新兴的生物疗法。
Joint Bone Spine. 2004 Nov;71(6):470-4. doi: 10.1016/j.jbspin.2004.07.008.
5
More sympathy for autoimmunity with neuropeptide Y?对神经肽Y介导的自身免疫是否应给予更多同情？
Trends Immunol. 2004 Oct;25(10):508-12. doi: 10.1016/j.it.2004.08.005.
6
Targeting cytokines beyond tumor necrosis factor-alpha and interleukin-1 in rheumatoid arthritis.在类风湿性关节炎中针对肿瘤坏死因子-α和白细胞介素-1以外的细胞因子
Curr Rheumatol Rep. 2004 Oct;6(5):336-42. doi: 10.1007/s11926-004-0007-2.
7
The role of substance P in inflammatory disease.P物质在炎症性疾病中的作用。
J Cell Physiol. 2004 Nov;201(2):167-80. doi: 10.1002/jcp.20061.
8
The significance of vasoactive intestinal peptide in immunomodulation.血管活性肠肽在免疫调节中的意义。
Pharmacol Rev. 2004 Jun;56(2):249-90. doi: 10.1124/pr.56.2.7.
9
A role for substance P in arthritis?
Neurosci Lett. 2004 May 6;361(1-3):176-9. doi: 10.1016/j.neulet.2003.12.020.
10
Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial.与单药治疗相比，依那西普与甲氨蝶呤联合治疗类风湿关节炎患者的疗效：双盲随机对照试验
Lancet. 2004 Feb 28;363(9410):675-81. doi: 10.1016/S0140-6736(04)15640-7.

类风湿关节炎中的胃泌素释放肽、P物质和细胞因子。

Gastrin-releasing peptide, substance P and cytokines in rheumatoid arthritis.

作者信息

Green Paul G

机构信息

Department of Oral and Maxillofacial Surgery, University of California San Francisco, San Francisco, CA, USA.

出版信息

Arthritis Res Ther. 2005;7(3):111-3. doi: 10.1186/ar1746. Epub 2005 Mar 30.

DOI:10.1186/ar1746
PMID:15899059
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1174968/
Abstract

Many studies have shown that modulation of cytokine function is effective in ameliorating symptoms of rheumatoid arthritis. Neuropeptides have recently been shown to have powerful effects on the production and release of cytokines and have also been shown to exert potent proinflammatory and anti-inflammatory effects in animal models of inflammatory diseases. An analysis of cytokine and neuropeptide content of synovial fluid from patients with rheumatoid arthritis has revealed a significant correlation between two neuropeptides, bombesin/gastrin-releasing peptide and substance P, and the proinflammatory cytokine interleukin-6 as well as the erythrocyte sedimentation rate. These findings provide further evidence for a role of neuropeptides and cytokines in the pathophysiology of rheumatoid arthritis, as well as suggesting additional approaches for the development of novel therapeutic interventions.

摘要

许多研究表明，调节细胞因子功能对改善类风湿性关节炎症状有效。最近发现神经肽对细胞因子的产生和释放有强大作用，并且在炎症性疾病的动物模型中也显示出具有强大的促炎和抗炎作用。对类风湿性关节炎患者滑液中细胞因子和神经肽含量的分析表明，两种神经肽，即蛙皮素/胃泌素释放肽和P物质，与促炎细胞因子白细胞介素-6以及红细胞沉降率之间存在显著相关性。这些发现为神经肽和细胞因子在类风湿性关节炎病理生理学中的作用提供了进一步证据，也为开发新型治疗干预措施提出了其他方法。