Department of Infectious Diseases and Immunology, Harvard School of Public Health, Boston, MA 02115, USA.
Immunol Rev. 2010 Jan;233(1):286-300. doi: 10.1111/j.0105-2896.2009.00849.x.
Osteoporosis and arthritis are highly prevalent diseases and a significant cause of morbidity and mortality worldwide. These diseases result from aberrant tissue remodeling leading to weak, fracture-prone bones or painful, dysfunctional joints. The nuclear factor of activated T cells (NFAT) transcription factor family controls diverse biologic processes in vertebrates. Here, we review the scientific evidence that links NFAT-regulated gene transcription to bone and joint pathology. A particular emphasis is placed on the role of NFATs in bone resorption and formation by osteoclasts and osteoblasts, respectively. In addition, emerging data that connect NFATs with cartilage biology, angiogenesis, nociception, and neurogenic inflammation are explored. The goal of this article is to highlight the importance of tissue remodeling in musculoskeletal disease and situate NFAT-driven cellular responses within this context to inspire future research endeavors.
骨质疏松症和关节炎是高发疾病，也是全球发病率和死亡率的重要原因。这些疾病源于组织异常重塑，导致骨骼脆弱易碎或关节疼痛、功能障碍。激活 T 细胞的核因子（NFAT）转录因子家族在脊椎动物中控制着多种生物学过程。在这里，我们回顾了将 NFAT 调节的基因转录与骨骼和关节病理学联系起来的科学证据。特别强调了 NFAT 在破骨细胞和成骨细胞分别介导的骨吸收和形成中的作用。此外，还探讨了将 NFAT 与软骨生物学、血管生成、伤害感受和神经原性炎症联系起来的新兴数据。本文的目的是强调组织重塑在肌肉骨骼疾病中的重要性，并将 NFAT 驱动的细胞反应置于这一背景下，以激发未来的研究工作。
